ABOUT AB308:ĪB308 is a second investigational anti-TIGIT monoclonal antibody that is Fc-enabled. a réaffirmé ses prévisions de bénéfices pour 2022. Domvanalimab is currently being evaluated in an ongoing Phase 3 registrational study in combination with zimberelimab, our anti-PD-1 monoclonal antibody in first-line locally advanced or metastatic, PD-L1>50% non-small cell lung cancer. This investigational medicine is designed to treat solid tumors because the silent Fc domain is believed to eliminate the potential for depletion of TIGIT-bearing immune cells, which are critical for anti-tumor immune activity. He received his BS from Massachusetts Institute of Technology, his MD from Dartmouth Medical School and his PhD at Harvard Medical School in the laboratory of David Corey. ABOUT DOMVANALIMAB:ĭomvanalimab, our most advanced anti-TIGIT candidate, is an Fc-silent investigational monoclonal antibody that blocks TIGIT and has demonstrated complete receptor coverage on all TIGIT-expressing peripheral leukocytes. Barres co-founded Annexon Biosciences and was a Professor and Chair of Neurobiology at Stanford University School of Medicine. Both bind to TIGIT and may enable CD155:CD226 interaction and subsequent immune cell activation. Arcus is developing two anti-TIGIT monoclonal antibodies: domvanalimab (Fc-silent) and AB308 (Fc-enabled). At Genocea Biosciences, a small biotech company, we face the challenge of performing clinical trials with limited resources, which at times can.
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